anti-NUP62 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes NUP62
  • 反应物种: Hu
  • 预测物种: Ms, Rat
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: NUP62
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG55475
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes NUP62
反应物种Hu
预测物种Ms, Rat
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称NUP62
抗原物种Human
抗原Recombinant protein of Human NUP62
偶联标记Un-conjugated
別名IBSN; p62; Nucleoporin Nup62; SNDI; 62 kDa nucleoporin; Nuclear pore glycoprotein p62
应用说明
应用建议
应用推荐稀释比
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照U937
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 23636 Human NUP62

Swiss-port # P37198 Human Nuclear pore glycoprotein p62

基因名称NUP62
全名nucleoporin 62kDa
背景介绍The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]
生物功能Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex. [UniProt]
研究领域Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Controls and Markers antibody; Gene Regulation antibody; Signaling Transduction antibody
预测分子量53 kDa
翻译后修饰O-glycosylated. Contains about 10 N-acetylglucosamine side chain sites predicted for the entire protein, among which only one in the C-terminal.
The the inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.
检测图片 (1)
  • ARG55475 anti-NUP62 antibody WB image

    Western blot: U937 cell lysate stained with ARG55475 anti-NUP62 antibody.

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