anti-Ogg1 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes Ogg1
  • 反应物种: Hu, Ms, Rat
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: Ogg1
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 1-345 of Human Ogg1 (NP_002533.1).
  • Brand:
CAT.NO. : ARG40520
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes Ogg1
反应物种Hu, Ms, Rat
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称Ogg1
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 1-345 of Human Ogg1 (NP_002533.1).
偶联标记Un-conjugated
別名EC 4.2.99.18; N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase; HOGG1; MUTM; OGH1; AP lyase; HMMH; apurinic or apyrimidinic site; EC 3.2.2.-
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:200
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Mouse heart
实际分子量36 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 18294 Mouse OGG1

GeneID: 4968 Human OGG1

GeneID: 81528 Rat OGG1

基因名称OGG1
全名8-oxoguanine DNA glycosylase
背景介绍This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
生物功能DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. [UniProt]
细胞定位Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. Isoform 1A: Nucleus. Isoform 2A: Mitochondrion. [UniProt]
预测分子量39 kDa
检测图片 (2)
  • ARG40520 anti-Ogg1 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Mouse brain stained with ARG40520 anti-Ogg1 antibody at 1:200 dilution.

  • ARG40520 anti-Ogg1 antibody WB image

    Western blot: 25 µg of Mouse heart lysate stained with ARG40520 anti-Ogg1 antibody at 1:1000 dilution.

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