anti-ORC1 antibody [7F6/1]
![anti-ORC1 antibody [7F6/1]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
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CAT.NO. : ARG62573
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [7F6/1] recognizes ORC1 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 7F6/1 |
| 同位型 | IgG1 |
| 靶点名称 | ORC1 |
| 抗原物种 | Human |
| 抗原 | Full length protein (Human) |
| 偶联标记 | Un-conjugated |
| 別名 | ORC1L; Replication control protein 1; PARC1; Origin recognition complex subunit 1; HSORC1 |
应用说明
| 应用说明 | WB: 1/1250 - 1/2500 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
属性
| 形式 | Liquid |
|---|---|
| 纯化 | IgG purified |
| 缓冲液 | 1X PBS buffer with |
| 抗菌剂 | |
| 浓度 | 2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q13415 Human Origin recognition complex subunit 1 |
|---|---|
| 基因名称 | ORC1 |
| 全名 | origin recognition complex, subunit 1 |
| 背景介绍 | The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| 生物功能 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. [UniProt] |
| 细胞定位 | Nucleus |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 97 kDa |
| 翻译后修饰 | Phosphorylated during mitosis. |
参考文献
克隆号文献
The role of PR-Set7 in replication licensing depends on Suv4-20h.
WB, ChIP / Human
HOXD13 binds DNA replication origins to promote origin licensing and is inhibited by geminin.
ChIP / Human, Mouse
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