anti-p53R2 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes p53R2
  • 反应物种: Hu, Ms, Rat
  • 应用: IHC-P, WB
  • 特异性: This antibody recognizes an epitope atthe N-terminus of human, mouse, andrat p53R2, a p53 inducible gene thatcontains a p53 binding sequence andencodes a subunit of the enzymeribonucleotide reductase. p53R2 isinduced by agents that cause DNAdamage, such as UV and γ-irradiation.The product of the p53R2 gene isdirectly involved in the p53 checkpointfor repair of damaged DNA.
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: p53R2
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG54620
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes p53R2
反应物种Hu, Ms, Rat
应用IHC-P, WB
特异性This antibody recognizes an epitope atthe N-terminus of human, mouse, andrat p53R2, a p53 inducible gene thatcontains a p53 binding sequence andencodes a subunit of the enzymeribonucleotide reductase. p53R2 isinduced by agents that cause DNAdamage, such as UV and γ-irradiation.The product of the p53R2 gene isdirectly involved in the p53 checkpointfor repair of damaged DNA.
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称p53R2
抗原物种Human
抗原Peptide corresponding to aa2-17 of human p53R2
偶联标记Un-conjugated
別名P53R2; EC 1.17.4.1; p53-inducible ribonucleotide reductase small subunit 2-like protein; TP53-inducible ribonucleotide reductase M2 B; Ribonucleoside-diphosphate reductase subunit M2 B; MTDPS8A; MTDPS8B; p53R2
应用说明
应用建议
应用推荐稀释比
IHC-P1 - 20 µg/ml
WB1 µg/ml
应用说明Western blot: use at 0.5 - 1 ug/ml. In immunoblots, a band of 39 kD is detected
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照A431
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液PBS (pH 7.4) and 0.02% Sodium azide
抗菌剂0.02% Sodium azide
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 382985 Mouse RRM2B

GeneID: 50484 Human RRM2B

Swiss-port # Q6PEE3 Mouse Ribonucleoside-diphosphate reductase subunit M2 B

Swiss-port # Q7LG56 Human Ribonucleoside-diphosphate reductase subunit M2 B

基因名称RRM2B
全名ribonucleotide reductase M2 B (TP53 inducible)
背景介绍This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
生物功能Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. [UniProt]
研究领域Cancer antibody; Gene Regulation antibody; Metabolism antibody
预测分子量41 kDa
检测图片 (3)
  • ARG54620 anti-p53R2 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human lung stained with ARG54620 anti-p53R2 antibody at 1 µg/ml dilution.

  • ARG54620 anti-p53R2 antibody WB image

    Western blot: A431 cell lysate stained with ARG54620 anti-p53R2 antibody at 1 µg/ml dilution.

  • ARG54620 anti-p53R2 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human lung stained with ARG54620 anti-p53R2 antibody at 20 μg/ml dilution.

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