anti-pan FGFA / FHFA antibody [S235-22]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [S235-22] recognizes pan FGFA / FHFA
  • 反应物种: Hu, Rat
  • 预测物种: Ms
  • 应用: ICC/IF, WB
  • 特异性: Does not cross-react with FGF13B / FHF2B. Cross reacts with FGF12A / FHF1A and FGF14A / FHF4A.
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: S235-22
  • 同位型: IgG2b
  • Brand:
CAT.NO. : ARG22357
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Product Details
概述
产品描述Mouse Monoclonal antibody [S235-22] recognizes pan FGFA / FHFA
反应物种Hu, Rat
预测物种Ms
应用ICC/IF, WB
特异性Does not cross-react with FGF13B / FHF2B. Cross reacts with FGF12A / FHF1A and FGF14A / FHF4A.
宿主Mouse
克隆Monoclonal
克隆号S235-22
同位型IgG2b
靶点名称pan FGFA / FHFA
抗原物种Human
抗原Synthetic peptide around aa. 2-18 of Human FHF2A (AAAIASSLIRQKRQARE). 100% identical to Rat, 94% identical to Mouse. > 80% identity with FGF12A/FHF1A, FGF14A/FHF4A and FGF11A/FHF3A.
偶联标记Un-conjugated
別名FHF-2; FHF2; Fibroblast growth factor 13; Fibroblast growth factor homologous factor 2; FGF-13; FGF2
应用说明
应用建议
应用推荐稀释比
ICC/IF1:100
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS (pH 7.4), 0.1% Sodium azide and 50% Glycerol.
抗菌剂0.1% Sodium azide
稳定剂50% Glycerol
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 2258 Human FGF13

GeneID: 84488 Rat FGF13

Swiss-port # Q92913 Human Fibroblast growth factor 13

Swiss-port # Q9ERW3 Rat Fibroblast growth factor 13

基因名称FGF13
全名fibroblast growth factor 13
背景介绍The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]
生物功能Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus.

May regulate voltage-gated sodium channels transport and function.

May also play a role in MAPK signaling. [UniProt]
预测分子量28 kDa
翻译后修饰May be phosphorylated.
检测图片 (2)
  • ARG22357 anti-pan FGFA / FHFA antibody [S235-22] ICC/IF image

    Immunocytochemistry: Human Neuroblastoma cell line SK-N-BE. Fixation: 4% Formaldehyde for 15 min at RT. Cells were stained with ARG22357 anti-pan FGFA / FHFA antibody [S235-22] at 1:100 dilution (60 min, RT). Magnification: 60X. (A) DAPI (blue) nuclear stain, (B) Phalloidin Texas Red F-Actin stain, (C) ARG22357 anti-pan FGFA / FHFA antibody [S235-22] (green), and (D) Composite.

  • ARG22357 anti-pan FGFA / FHFA antibody [S235-22] WB image

    Western blot: 15 µg of Rat brain membrane stained with ARG22357 anti-pan FGFA / FHFA antibody [S235-22] at 1:200 dilution (16 hours, 4°C). Block: 2% BSA and 2% Skim Milk in 1X TBST. .

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