anti-Paxillin antibody [PXC-10, aka PAX-14]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [PXC-10, aka PAX-14] recognizes Paxillin
  • 反应物种: Hu, Ms, Rat
  • 预测物种: Chk
  • 应用: WB
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: PXC-10, aka PAX-14
  • 同位型: IgG1
  • 靶点名称: Paxillin
  • Brand:
CAT.NO. : ARG58203
US$ Please choose
US$ Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整,请以品牌方官网实时更新的价格为准,以确保准确性。
Product Details
概述
产品描述Mouse Monoclonal antibody [PXC-10, aka PAX-14] recognizes Paxillin
反应物种Hu, Ms, Rat
预测物种Chk
应用WB
宿主Mouse
克隆Monoclonal
克隆号PXC-10, aka PAX-14
同位型IgG1
靶点名称Paxillin
抗原物种Chicken
抗原C-terminal partial recombinant protein corresponding to aa. 305-559 of Chicken Paxillin.
偶联标记Un-conjugated
別名Paxillin
应用说明
应用建议
应用推荐稀释比
WB1 - 2 µg/ml
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Ascites
缓冲液PBS, 0.01% Sodium azide and 1% BSA.
抗菌剂0.01% Sodium azide
稳定剂1% BSA
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 19303 Mouse PXN

GeneID: 360820 Rat PXN

GeneID: 5829 Human PXN

基因名称PXN
全名paxillin
背景介绍This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
生物功能Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). [UniProt]
预测分子量61/65/66 kDa (Isoform alpha/beta/gamma)
翻译后修饰Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (PubMed:23128389). [UniProt]
检测图片 (1)
  • ARG58203 anti-Paxillin antibody [PXC-10, aka PAX-14] WB image

    Western blot: 1) 293T, 2) HeLa, 3) MCF-7, 4) MDA-MB-231 and 5) Jurkat cell lysates stained with ARG58203 anti-Paxillin antibody [PXC-10, aka PAX-14].

New Products
Get in touch with AREX
Name:*
Tel/Phone:*
Company:*
Email:*
Inquiry:
Captcha*
Submitting your email information means that you are willing to receive email information from AREX regarding technology, applications, products, and events. By clicking on the 'unsubscribe' button in the email or by contacting info@arexbio.com You can unsubscribe at any time by sending an email. Regarding your data usage information, please refer to our privacy policy.
© AREX 2024. All Rights Reserved. | 浙ICP备2024113709号-3 Sitemap