anti-PDCD10 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG66403
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PDCD10 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PDCD10 |
| 抗原物种 | Human |
| 抗原 | Fusion protein of Human PDCD10. |
| 偶联标记 | Un-conjugated |
| 別名 | Cerebral cavernous malformations 3 protein; Programmed cell death protein 10; TF-1 cell apoptosis-related protein 15; CCM3; TFAR15 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | WB: HeLa, Jurkat and 231 cells. IHC-P: Human tonsil and Human renal cancer. | ||||||
| 实际分子量 | ~ 27 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 40% Glycerol. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 40% Glycerol |
| 浓度 | 0.6 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PDCD10 |
| 全名 | programmed cell death 10 |
| 背景介绍 | This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
| 生物功能 | Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). [UniProt] |
| 细胞定位 | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially co-localizes with endogenous PXN at the leading edges of migrating cells. [UniProt] |
| 预测分子量 | 25 kDa |
检测图片 (3)
ARG66403 anti-PDCD10 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human tonsil stained with ARG66403 anti-PDCD10 antibody (left) at 1:20 dilution, or the same antibody pre-incubated with antigen (right). (Original magnification: X200).
ARG66403 anti-PDCD10 antibody WB image
Western blot: 50 µg of HeLa, Jurkat and 231 cell lysates stained with ARG66403 anti-PDCD10 antibody at 1:200 dilution.
ARG66403 anti-PDCD10 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human renal cancer stained with ARG66403 anti-PDCD10 antibody (left) at 1:20 dilution, or the same antibody pre-incubated with antigen (right). (Original magnification: X200).
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