anti-PDE10A antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes PDE10A
  • 反应物种: Hu, Ms, Rat, Mk
  • 应用: Confocal, Dot, ELISA, ICC/IF, IHC, IP, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: PDE10A
  • 抗原物种: Human
  • 抗原: Synthetic multiple antigenic peptide around the aa. 250-325 of Human PDE10A.
  • Brand:
CAT.NO. : ARG10786
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes PDE10A
反应物种Hu, Ms, Rat, Mk
应用Confocal, Dot, ELISA, ICC/IF, IHC, IP, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称PDE10A
抗原物种Human
抗原Synthetic multiple antigenic peptide around the aa. 250-325 of Human PDE10A.
偶联标记Un-conjugated
別名HSPDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; EC 3.1.4.17; EC 3.1.4.35
应用说明
应用建议
应用推荐稀释比
Confocal1:100 - 1:150
Dot1:10000
ELISA1:10000
ICC/IF1:100 - 1:150
IHC1:100 - 1:150
IP1:200
WB1:500
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purified.
缓冲液Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA.
抗菌剂0.02% Sodium azide
稳定剂30% Glycerol and 0.5% BSA
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 10846 Human PDE10A

GeneID: 23984 Mouse PDE10A

GeneID: 63885 Rat PDE10A

基因名称PDE10A
全名phosphodiesterase 10A
背景介绍The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
生物功能Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. [UniProt]
预测分子量88 kDa
翻译后修饰Isoform PDE10A2: Phosphorylated on Thr-16.
检测图片 (3)
  • ARG10786 anti-PDE10A antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat testis tissue section. A) Negative control, B) Stained with ARG10786 anti-PDE10A antibody at 1:200 dilution.

  • ARG10786 anti-PDE10A antibody WB image

    Western blot: Rat samples: 1) frontal cortex, 2) parietal cortex, 3) striatum, 4) amygdala, 5) hypothalamus, 6) hippocampus, 7) olfactory bulb, 8) brain stem, 9) cerebellum, 10) spinal cord, and 11) whole brain lysates stained with ARG10786 anti-PDE10A antibody at 1:500 dilution.

  • ARG10786 anti-PDE10A antibody WB image

    Western blot: Rat striatum lysates stained with ARG10786 anti-PDE10A antibody at 1:500 dilution.

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