anti-PDE3A antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG10796
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PDE3A |
|---|---|
| 反应物种 | Hu, Ms, Rat, Mk, Xenopus |
| 应用 | Confocal, Dot, ELISA, FRET, ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PDE3A |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide selective only for PDE3A variants. |
| 偶联标记 | Un-conjugated |
| 別名 | EC 3.1.4.17; Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE; CGI-PDE A; CGI-PDE-A; HTNB; cGMP-inhibited 3',5'-cyclic phosphodiesterase A |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 30% Glycerol and 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PDE3A |
| 全名 | phosphodiesterase 3A, cGMP-inhibited |
| 背景介绍 | This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] |
| 生物功能 | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. [UniProt] |
| 预测分子量 | 125 kDa |
检测图片 (2)
ARG10796 anti-PDE3A antibody ICC/IF image
Immunofluorescence: Ice-cold Acetone/Methanol (1:1) fixed (5 min) cultured rat smooth muscle cells stained with ARG10796anti-PDE3A antibody (red) at 1:100 dilution. Nuclei were counterstained with DAPI (blue).
ARG10796 anti-PDE3A antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human ovarian medulla tissue stained with ARG10796 anti-PDE3A antibody at 1:100 dilution.
参考文献
Electroacupuncture promotes the gastrointestinal motility of diabetic mice by CNP/NPR-B-cGMP and PDE3A-cGMP signaling.
WB / Mouse
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