anti-PDE4D antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG55469
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PDE4D |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PDE4D |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human PDE4D |
| 偶联标记 | Un-conjugated |
| 別名 | EC 3.1.4.53; STRK1; DPDE3; PDE43; ACRDYS2; PDE4DN2; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; HSPDE4D |
应用说明
| 预测反应性说明 | Mouse, Rat | ||||||
|---|---|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | SW480 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PDE4D |
| 全名 | phosphodiesterase 4D, cAMP-specific |
| 背景介绍 | This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009] |
| 生物功能 | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. [UniProt] |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 91 kDa |
| 翻译后修饰 | Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are activated by PKA through phosphorylation (By similarity). Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59. Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation. |
检测图片 (1)
ARG55469 anti-PDE4D antibody WB image
Western blot: SW480 cell lysate stained with ARG55469 anti-PDE4D antibody.
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