anti-PDE8A antibody [EM-52]
![anti-PDE8A antibody [EM-52]](/upload/image/products/ARG42375_WB_1_210_205.jpg)
![anti-PDE8A antibody [EM-52]](/upload/image/products/ARG42375_WB_1.jpg)
Key features and details
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CAT.NO. : ARG42375
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [EM-52] recognizes PDE8A |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 特异性 | The mouse monoclonal antibody EM-52 recognizes PDE8a (phosphodiesterase 8 A), an approximately 93 kDa intracellular enzyme that hydrolyzes cAMP to 5'AMP. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | EM-52 |
| 同位型 | IgG1, kappa |
| 靶点名称 | PDE8A |
| 抗原物种 | Human |
| 抗原 | Human PDE8A. |
| 偶联标记 | Un-conjugated |
| 別名 | HsT19550; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; EC 3.1.4.53 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # O60658 Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiest |
|---|---|
| 基因名称 | PDE8A |
| 全名 | phosphodiesterase 8A |
| 背景介绍 | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
| 生物功能 | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). [UniProt] |
| 预测分子量 | 93 kDa |
| 翻译后修饰 | Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity. [UniProt] |
检测图片 (1)
ARG42375 anti-PDE8A antibody [EM-52] WB image
Western blot: PDE8A-transfected HEK293T/17. Cell lysate was stained with ARG42375 anti-PDE8A antibody [EM-52], under reducing conditions.
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