anti-PDK1 / Mitochondrial Pyruvate Dehydrogenase Kinase 1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG40874
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PDK1 / Mitochondrial Pyruvate Dehydrogenase Kinase 1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PDK1 / Mitochondrial Pyruvate Dehydrogenase Kinase 1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human PDK1. |
| 偶联标记 | Un-conjugated |
| 別名 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; EC 2.7.11.2; Pyruvate dehydrogenase kinase isoform 1; PDH kinase 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q15118 Human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochond Swiss-port # Q8BFP9 Mouse [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochond |
|---|---|
| 基因名称 | PDK1 |
| 全名 | pyruvate dehydrogenase kinase, isozyme 1 |
| 背景介绍 | Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013] |
| 生物功能 | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. [UniProt] |
| 细胞定位 | Mitochondrion matrix. [UniProt] |
| 预测分子量 | 49 kDa |
| 翻译后修饰 | Phosphorylated by constitutively activated ABL1, FGFR1, FLT3 and JAK2 (in vitro), and this may also occur in cancer cells that express constitutively activated ABL1, FGFR1, FLT3 and JAK2. Phosphorylation at Tyr-243 and Tyr-244 strongly increases kinase activity, while phosphorylation at Tyr-136 has a lesser effect. [UniProt] |
检测图片 (1)
ARG40874 anti-PDK1 / Mitochondrial Pyruvate Dehydrogenase Kinase 1 antibody WB image
Western blot: LNCaP cell lysate stained with ARG40874 anti-PDK1 / Mitochondrial Pyruvate Dehydrogenase Kinase 1 antibody.
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