anti-PDX1 phospho (Ser61) antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG43796
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PDX1 phospho (Ser61). |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Bov, Chk, Dog, Hrs, Pig, Rb, Sheep, Xenopus |
| 应用 | ICC/IF, IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PDX1 |
| 抗原物种 | Human |
| 抗原 | Synthetic phosphopeptide around Ser61 of Human PDX1. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Pancreas/duodenum homeobox protein 1 |
| 別名 | IPF1; Glucose-sensitive factor; Somatostatin-transactivating factor 1; Pancreas/duodenum homeobox protein 1; GSF; Insulin upstream factor 1; IUF-1; IUF1; IDX-1; Insulin promoter factor 1; MODY4; PDX-1; PAGEN1; IPF-1; STF-1; Islet/duodenum homeobox-1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human Overian; HepG2 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P52945 Human Pancreas/duodenum homeobox protein 1 |
|---|---|
| 基因名称 | PDX1 |
| 全名 | pancreatic and duodenal homeobox 1 |
| 背景介绍 | The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008] |
| 生物功能 | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. [UniProt] |
| 细胞定位 | Nucleus. Cytoplasm, cytosol. [UniProt] |
| 预测分子量 | 31 kDa |
| 翻译后修饰 | Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol (By similarity). [UniProt] |
检测图片 (2)
ARG43796 anti-PDX1 phospho (Ser61) antibody ICC/IF image
Immunofluorescence: HepG2 cells were blocked with 10% goat serum and then stained with ARG43796 anti-PDX1 phospho (Ser61) antibody (red) at 37°C for 1 hour. DAPI (blue) for nuclear staining.
ARG43796 anti-PDX1 phospho (Ser61) antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human Overian tissue stained with ARG43796 aanti-PDX1 phospho (Ser61) antibody.
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