anti-PEA15 antibody [4D2]
![anti-PEA15 antibody [4D2]](/upload/image/products/ARG11125_WB_1_210_205.jpg)
![anti-PEA15 antibody [4D2]](/upload/image/products/ARG11125_IHC-Fr_1.jpg)
![anti-PEA15 antibody [4D2]](/upload/image/products/ARG11125_WB_1.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG11125
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [4D2] recognizes PEA15 |
|---|---|
| 反应物种 | Ms, Rat, Cow |
| 预测物种 | Hu |
| 应用 | IHC-Fr, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 4D2 |
| 同位型 | IgG1 |
| 靶点名称 | PEA15 |
| 抗原物种 | Human |
| 抗原 | Full-length Human PEA15. |
| 偶联标记 | Un-conjugated |
| 別名 | MAT1H; MAT1; Astrocytic phosphoprotein PEA-15; HUMMAT1H; 15 kDa phosphoprotein enriched in astrocytes; PED; PEA-15; Phosphoprotein enriched in diabetes; HMAT1 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | ~ 15 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS, 5 mM Sodium azide and 50% Glycerol. |
| 抗菌剂 | 5 mM Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PEA15 |
| 全名 | phosphoprotein enriched in astrocytes 15 |
| 背景介绍 | This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| 生物功能 | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. [UniProt] |
| 细胞定位 | Cytoplasm. Note=Associated with microtubules. [UniProt] |
| 预测分子量 | 15 kDa |
| 翻译后修饰 | Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones. [UniProt] |
检测图片 (2)
ARG11125 anti-PEA15 antibody [4D2] IHC-Fr image
Immunohistochemistry: Frozen section of Rat brain tissue stained with ARG11125 anti-PEA15 antibody [4D2] (red) at 1:1000 dilution, and co-stained with anti-GFAP antibody (green) at 1:5000 dilution. Hoechst (blue) for nuclear staining. (Sample preparation: Following transcardial perfusion of rat with 4% paraformaldehyde, brain was post fixed for 24 hours, cut to 45 µM, and free-floating sections were stained with above antibodies.).
ARG11125 anti-PEA15 antibody [4D2] WB image
Western blot: Rat whole brain, Rat cerebellum, Mouse whole brain, Cow cortex and Cow cerebellum lysates stained with ARG11125 anti-PEA15 antibody [4D2] at 1:1000 dilution.
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