anti-PHF10 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG44517
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PHF10 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PHF10 |
| 抗原物种 | Human |
| 抗原 | Human PHF10 recombinant protein |
| 偶联标记 | Un-conjugated |
| 別名 | PHF10; PHD Finger Protein 10; XAP135; BAF45a; SMARCG4; BRG1-Associated Factor 45a; FLJ10975; BRG1-Associated Factor, 45-KD, A; PHD Zinc Finger Protein XAP135; BAF45A |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PHF10 |
| 全名 | PHD Finger Protein 10 |
| 背景介绍 | This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. |
| 生物功能 | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growt. |
| 细胞定位 | Nucleus |
| 预测分子量 | 56 kDa |
| 翻译后修饰 | Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation |
检测图片 (4)
ARG44517 anti-PHF10 antibody WB image
Western blot: U-87MG and U251 stained with ARG44517 anti-PHF10 antibody at 0.5 μg/mL dilution.
ARG44517 anti-PHF10 antibody FACS image
Flow Cytometry: K562 stained with ARG44517 anti-PHF10 antibody at 1 μg/10^6 cells dilution.
ARG44517 anti-PHF10 antibody WB image
Western blot: C6 stained with ARG44517 anti-PHF10 antibody at 0.5 μg/mL dilution.
ARG44517 anti-PHF10 antibody WB image
Western blot: Neuro-2a stained with ARG44517 anti-PHF10 antibody at 0.5 μg/mL dilution.
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