anti-Phospho-PDE5A antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes PDE5A
  • 反应物种: Hu, Ms, Rat, Bov, Pig
  • 应用: Confocal, Dot, ELISA, ICC/IF, IHC, IP, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: PDE5A
  • 抗原物种: Human
  • 抗原: Phosphorylated peptide taken within aa. 120-170 from Human PDE5A.
  • Brand:
CAT.NO. : ARG10820
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes PDE5A
反应物种Hu, Ms, Rat, Bov, Pig
应用Confocal, Dot, ELISA, ICC/IF, IHC, IP, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称PDE5A
抗原物种Human
抗原Phosphorylated peptide taken within aa. 120-170 from Human PDE5A.
偶联标记Un-conjugated
別名cGMP-specific 3',5'-cyclic phosphodiesterase; CN5A; CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase; PDE5; EC 3.1.4.35
应用说明
应用建议
应用推荐稀释比
Confocal1:100
Dot1:10000
ELISA1:10000
ICC/IF1:100
IHC1:100
IP1:200
WB1:500
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purified.
缓冲液Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA.
抗菌剂0.02% Sodium azide
稳定剂30% Glycerol and 0.5% BSA
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 171115 Rat PDE5A

GeneID: 242202 Mouse PDE5A

GeneID: 281972 Bovine PDE5A

基因名称PDE5A
全名phosphodiesterase 5A, cGMP-specific
背景介绍This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
生物功能Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. [UniProt]
预测分子量100 kDa
翻译后修饰Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity). Phosphorylation by PRKG1 leads to its activation.
检测图片 (1)
  • ARG10820 anti-Phospho-PDE5A antibody WB image

    Western blot: Human PDE5A-GFP overexpressing cells untreated or treated with ANP. The blots were stained with ARG10820 anti-Phospho-PDE5A antibody at 1:500 dilution.

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