anti-PLVAP antibody [MECA-32]
![anti-PLVAP antibody [MECA-32]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
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- 克隆:
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- 靶点名称:
- 抗原物种:
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CAT.NO. : ARG23271
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Product Details
概述
| 产品描述 | Rat Monoclonal antibody [MECA-32] recognizes PLVAP Rat anti Mouse PLVAP antibody, clone MECA-32 recognizes murine plasmalemma vesicle-associated protein (PLVAP), a ~60 kDa protein also known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumour angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target. |
|---|---|
| 反应物种 | Ms |
| 应用 | FACS, IHC-Fr |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | MECA-32 |
| 同位型 | IgG2a |
| 靶点名称 | PLVAP |
| 抗原物种 | Mouse |
| 偶联标记 | Un-conjugated |
| 別名 | PV1; Plasmalemma vesicle-associated protein; PV-1; Fenestrated endothelial-linked structure protein; FELS; gp68; Plasmalemma vesicle protein 1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% Sodium azide. |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q91VC4 Mouse Plasmalemma vesicle-associated protein |
|---|---|
| 基因名称 | PLVAP |
| 全名 | plasmalemma vesicle associated protein |
| 生物功能 | Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability. [UniProt] |
| 预测分子量 | 51 kDa |
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