anti-POLR2B antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes POLR2B
  • 反应物种: Hu, Ms, Rat
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: POLR2B
  • 抗原物种: Human
  • 抗原: Recombinant protein of Human POLR2B.
  • Brand:
CAT.NO. : ARG57646
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes POLR2B
反应物种Hu, Ms, Rat
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称POLR2B
抗原物种Human
抗原Recombinant protein of Human POLR2B.
偶联标记Un-conjugated
別名RNA polymerase II subunit 2; RPB2; POL2RB; DNA-directed RNA polymerase II subunit B; DNA-directed RNA polymerase II 140 kDa polypeptide; RNA polymerase II subunit B2; DNA-directed RNA polymerase II subunit RPB2; hRPB140; EC 2.7.7.6
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:200
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照HepG2
实际分子量~ 134 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 231329 Mouse POLR2B

GeneID: 5431 Human POLR2B

Swiss-port # P30876 Human DNA-directed RNA polymerase II subunit RPB2

Swiss-port # Q8CFI7 Mouse DNA-directed RNA polymerase II subunit RPB2

基因名称POLR2B
全名polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
背景介绍This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
生物功能DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity). [UniProt]
细胞定位Nucleus [UniProt]
预测分子量134 kDa
检测图片 (2)
  • ARG57646 anti-POLR2B antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat liver stained with ARG57646 anti-POLR2B antibody at 1:100 dilution.

  • ARG57646 anti-POLR2B antibody WB image

    Western blot: 25 µg of HepG2 cell lysate stained with ARG57646 anti-POLR2B antibody at 1:1000 dilution.

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