anti-POT1 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes POT1
  • 反应物种: Hu, Ms
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: POT1
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 497-634 of Human POT1 (NP_056265.2).
  • Brand:
CAT.NO. : ARG59378
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes POT1
反应物种Hu, Ms
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称POT1
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 497-634 of Human POT1 (NP_056265.2).
偶联标记Un-conjugated
別名hPot1; CMM10; POT1-like telomere end-binding protein; Protection of telomeres protein 1; HPOT1
应用说明
应用建议
应用推荐稀释比
WB1:200 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照DU145
实际分子量75 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 25913 Human POT1

Swiss-port # Q9NUX5 Human Protection of telomeres protein 1

基因名称POT1
全名protection of telomeres 1
背景介绍This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
生物功能Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. [UniProt]
细胞定位Nucleus. Chromosome, telomere. Note=Colocalizes with telomeric DNA. [UniProt]
预测分子量71 kDa
检测图片 (1)
  • ARG59378 anti-POT1 antibody WB image

    Western blot: 25 µg of DU145 cell lysate stained with ARG59378 anti-POT1 antibody at 1:1000 dilution.

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