anti-PPME1 antibody [29G3]
![anti-PPME1 antibody [29G3]](/upload/image/products/ARG57085_WB_1_210_205.jpg)
![anti-PPME1 antibody [29G3]](/upload/image/products/ARG57085_WB_1.jpg)
Key features and details
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- 克隆:
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- 抗原物种:
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CAT.NO. : ARG57085
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [29G3] recognizes PPME1 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 29G3 |
| 同位型 | IgG1, kappa |
| 靶点名称 | PPME1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment around aa. 1-386 of Human PPME1. |
| 偶联标记 | Un-conjugated |
| 別名 | PME-1; EC 3.1.1.89; Protein phosphatase methylesterase 1 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 10% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9Y570 Human Protein phosphatase methylesterase 1 |
|---|---|
| 基因名称 | PPME1 |
| 全名 | protein phosphatase methylesterase 1 |
| 背景介绍 | This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] |
| 生物功能 | Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. [UniProt] |
| 预测分子量 | 42 kDa |
| 翻译后修饰 | Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1. |
检测图片 (1)
ARG57085 anti-PPME1 antibody [29G3] WB image
Western blot: 40 µg of 1) HeLa cell lysate, 2) K562 cell lysate, 3) A549 cell lysate stained with ARG57085 anti-PPME1 antibody [29G3] at 1:1000.
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