anti-PR3 antibody [MCPR3-2]
![anti-PR3 antibody [MCPR3-2]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
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CAT.NO. : ARG62602
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [MCPR3-2] recognizes PR3 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MCPR3-2 |
| 同位型 | IgG1 |
| 靶点名称 | PR3 |
| 抗原 | HMC-1/PR3 cell granule extract |
| 偶联标记 | Un-conjugated |
| 別名 | EC 3.4.21.76; MBN; Neutrophil proteinase 4; PR-3; Wegener autoantigen; AGP7; CANCA; C-ANCA antigen; C-ANCA; Leukocyte proteinase 3; ACPA; PR3; NP-4; MBT; NP4; Myeloblastin; P29 |
应用说明
| 应用说明 | FACS: 0.1µg for 106 cells * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G purified |
| 缓冲液 | 1X PBS buffer with 0.1% sodium azide. |
| 抗菌剂 | 0.1% sodium azide. |
| 浓度 | 2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PRTN3 |
| 全名 | proteinase 3 |
| 生物功能 | Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. [UniProt] |
| 研究领域 | Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 28 kDa |
参考文献
克隆号文献
A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors.
FACS / Human
Capture-ELISA based on recombinant PR3 is sensitive for PR3-ANCA testing and allows detection of PR3 and PR3-ANCA/PR3 immunecomplexes.
WB / Human
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