anti-PRAME antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG40092
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PRAME |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PRAME |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-200 of Human PRAME (NP_006106.1). |
| 偶联标记 | Un-conjugated |
| 別名 | OIP4; MAPE; Melanoma antigen preferentially expressed in tumors; CT130; OIP-4; Preferentially expressed antigen of melanoma; Opa-interacting protein 4 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Rat lung, Mouse liver and U2OS | ||||
| 实际分子量 | 58 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P78395 Human Melanoma antigen preferentially expressed in tumors |
|---|---|
| 基因名称 | PRAME |
| 全名 | preferentially expressed antigen in melanoma |
| 背景介绍 | This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| 生物功能 | Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. [UniProt] |
| 细胞定位 | Nucleus. Cell membrane. [UniProt] |
| 预测分子量 | 58 kDa |
检测图片 (1)
ARG40092 anti-PRAME antibody WB image
Western blot: 25 µg of Rat lung, Mouse liver and U2OS cell lysates stained with ARG40092 anti-PRAME antibody at 1:3000 dilution.
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