anti-PSMD2 / Proteasome 26S S2 antibody
Key features and details
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- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG55473
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PSMD2 / Proteasome 26S S2 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PSMD2 / Proteasome 26S S2 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human PSMD2 |
| 偶联标记 | Un-conjugated |
| 別名 | RPN1; TRAP2; 26S proteasome subunit p97; S2; Protein 55.11; P97; 26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit S2; 26S proteasome regulatory subunit RPN1; Tumor necrosis factor type 1 receptor-associated protein 2 |
应用说明
| 预测反应性说明 | Rat | ||||||
|---|---|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | SW480 and Mouse liver | ||||||
| 实际分子量 | ~ 100 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q13200 Human 26S proteasome non-ATPase regulatory subunit 2 Swiss-port # Q8VDM4 Mouse 26S proteasome non-ATPase regulatory subunit 2 |
|---|---|
| 基因名称 | PSMD2 |
| 全名 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 |
| 背景介绍 | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
| 生物功能 | Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody |
| 预测分子量 | 100 kDa |
检测图片 (3)
ARG55473 anti-PSMD2 / Proteasome 26S S2 antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG55473 anti-PSMD2 / Proteasome 26S S2 antibody.
ARG55473 anti-PSMD2 / Proteasome 26S S2 antibody WB image
Western blot: SW480 cell lysate stained with ARG55473 anti-PSMD2 / Proteasome 26S S2 antibody.
ARG55473 anti-PSMD2 / Proteasome 26S S2 antibody WB image
Western blot: Mouse liver lysate stained with ARG55473 anti-PSMD2 / Proteasome 26S S2 antibody.
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