anti-PTHLH antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes PTHLH
  • 反应物种: Hu, Ms, Rat
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: PTHLH
  • 抗原物种: Human
  • 抗原: Recombinant protein of Human PTHLH.
  • Brand:
CAT.NO. : ARG56411
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes PTHLH
反应物种Hu, Ms, Rat
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称PTHLH
抗原物种Human
抗原Recombinant protein of Human PTHLH.
偶联标记Un-conjugated
別名Parathyroid hormone-related protein; PTH-rP; PLP; PTHrP[107-139]; PTHRP; Parathyroid hormone-like protein; PTHR; PTHrP; HHM; BDE2
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:200
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照A549
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 24695 Rat PTHLH

GeneID: 5744 Human PTHLH

Swiss-port # P12272 Human Parathyroid hormone-related protein

Swiss-port # P13085 Rat Parathyroid hormone-related protein

基因名称PTHLH
全名parathyroid hormone-like hormone
背景介绍The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]
生物功能Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.

Osteostatin is a potent inhibitor of osteoclastic bone resorption. [UniProt]
预测分子量20 kDa
翻译后修饰There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.
检测图片 (2)
  • ARG56411 anti-PTHLH antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Mouse brain stained with ARG56411 anti-PTHLH antibody at 1:200 dilution.

  • ARG56411 anti-PTHLH antibody WB image

    Western blot: A549 cell lysate stained with ARG56411 anti-PTHLH antibody.

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