anti-PTPN13 / FAP1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG40547
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PTPN13 / FAP1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PTPN13 / FAP1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 250-500 of Human PTPN13 / FAP1 (NP_542416.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Protein-tyrosine phosphatase 1E; hPTP1E; PTPLE; hPTPE1; PNP1; Tyrosine-protein phosphatase non-receptor type 13; PTP1E; PTP-BL; PTP-E1; FAP-1; Protein-tyrosine phosphatase PTPL1; Fas-associated protein-tyrosine phosphatase 1; PTP-BAS; PTPL1; EC 3.1.3.48 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | A549 | ||||||
| 实际分子量 | 310 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q12923 Human Tyrosine-protein phosphatase non-receptor type 13 Swiss-port # Q64512 Mouse Tyrosine-protein phosphatase non-receptor type 13 |
|---|---|
| 基因名称 | PTPN13 |
| 全名 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) |
| 背景介绍 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008] |
| 生物功能 | Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2. [UniProt] |
| 细胞定位 | Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium. Note=Colocalizes with F-actin. Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover. [UniProt] |
| 预测分子量 | 277 kDa |
检测图片 (2)
ARG40547 anti-PTPN13 / FAP1 antibody WB image
Western blot: 25 µg of A549 cell lysate stained with ARG40547 anti-PTPN13 / FAP1 antibody at 1:3000 dilution.
ARG40547 anti-PTPN13 / FAP1 antibody WB image
Western blot: 25 µg of Mouse lung lysate stained with ARG40547 anti-PTPN13 / FAP1 antibody at 1:3000 dilution.
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