anti-RAB11A / YL8 antibody
CAT.NO. : ARG55646
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概述
产品描述 | Mouse Monoclonal antibody recognizes RAB11A / YL8 |
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反应物种 | Hu, Ms, Rat |
预测物种 | Chk, Dog, Sheep |
应用 | IHC-P, WB |
宿主 | Mouse |
克隆 | Monoclonal |
克隆号 | 1565CT164.36.80 |
同位型 | IgG1, kappa |
靶点名称 | RAB11A / YL8 |
抗原物种 | Human |
抗原 | Recombinant protein corresponding to aa. 1-216 of Human RAB11A. |
偶联标记 | Un-conjugated |
別名 | Rab-11; Ras-related protein Rab-11A; YL8 |
应用说明
应用建议 |
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应用说明 | IHC-P: Antigen Retrieval: Heat mediation was performed in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
阳性对照 | HeLa |
属性
形式 | Liquid |
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纯化 | Purification with Protein G. |
缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
抗菌剂 | 0.09% (W/V) Sodium azide |
存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
数据库连接 | |
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基因名称 | RAB11A |
全名 | RAB11A, member RAS oncogene family |
背景介绍 | The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] |
生物功能 | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes. [UniProt] |
预测分子量 | 24 kDa |
检测图片 (2)
ARG55646 anti-RAB11A / YL8 antibody IHC-P image
Immunohistochemistry: Paraformaldehyde-fixed and paraffin-embedded Human brain tissue stained with ARG55646 anti-RAB11A / YL8 antibody at 1:25 dilution for 1 hour at 37°C. Tissue was blocked with 3% BSA for 0.5 hour at room temperature. Antigen Retrieval: Heat mediation was performed in Citrate buffer (pH 6.0).
ARG55646 anti-RAB11A / YL8 antibody WB image
Western blot: 20 µg of HeLa whole cell lysate stained with ARG55646 anti-RAB11A / YL8 antibody at 1:4000 dilution.
