anti-RAD18 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes RAD18
  • 反应物种: Hu
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: RAD18
  • 抗原物种: Human
  • 抗原: Recombinant protein of Human RAD18.
  • Brand:
CAT.NO. : ARG56880
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes RAD18
反应物种Hu
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称RAD18
抗原物种Human
抗原Recombinant protein of Human RAD18.
偶联标记Un-conjugated
別名RING finger protein 73; RNF73; EC 6.3.2.-; E3 ubiquitin-protein ligase RAD18; hRAD18; hHR18; Postreplication repair protein RAD18
应用说明
应用建议
应用推荐稀释比
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照K562
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 56852 Human RAD18

Swiss-port # Q9NS91 Human E3 ubiquitin-protein ligase RAD18

基因名称RAD18
全名RAD18 E3 ubiquitin protein ligase
背景介绍The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
生物功能E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. [UniProt]
预测分子量56 kDa
检测图片 (1)
  • ARG56880 anti-RAD18 antibody WB image

    Western blot: K562 cell lysate stained with ARG56880 anti-RAD18 antibody.

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