anti-RAP80 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG59955
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Size:
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes RAP80 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | RAP80 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-230 of Human RAP80 (NP_057374.3). |
| 偶联标记 | Un-conjugated |
| 別名 | RAP80; Retinoid X receptor-interacting protein 110; Receptor-associated protein 80; Ubiquitin interaction motif-containing protein 1; X2HRIP110; BRCA1-A complex subunit RAP80 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | UIMC1 |
| 全名 | ubiquitin interaction motif containing 1 |
| 生物功能 | Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. [UniProt] |
| 细胞定位 | Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). [UniProt] |
| 预测分子量 | 80 kDa |
| 翻译后修饰 | Sumoylated. Phosphorylated upon DNA damage by ATM or ATR. [UniProt] |
检测图片 (1)
ARG59955 anti-RAP80 antibody ICC/IF image
Immunofluorescence: GFP-RNF168 transgenic U2OS cells stained with ARG59955 anti-RAP80 antibody (Red). Green: GFP-RNF168 fusion protein expression for DNA damage marker. Blue: DAPI for nuclear staining. GFP-RNF168 can be used to mark cells damaged by UV-A laser for they always gather around DNA damage region.
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