anti-RelB antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes RelB
  • 反应物种: Hu, Ms, Rat
  • 应用: FACS, ICC/IF, IHC-P, IP, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: RelB
  • 抗原物种: Human
  • 抗原: Synthetic peptide derived from Human RelB.
  • Brand:
CAT.NO. : ARG59706
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes RelB
反应物种Hu, Ms, Rat
应用FACS, ICC/IF, IHC-P, IP, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称RelB
抗原物种Human
抗原Synthetic peptide derived from Human RelB.
偶联标记Un-conjugated
別名REL-B; IREL; I-Rel; I-REL; Transcription factor RelB
应用说明
应用建议
应用推荐稀释比
FACS1:40
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
IP1:50
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Raji
实际分子量~ 70 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 19698 Mouse RELB

GeneID: 5971 Human RELB

Swiss-port # Q01201 Human Transcription factor RelB

Swiss-port # Q04863 Mouse Transcription factor RelB

基因名称RELB
全名v-rel avian reticuloendotheliosis viral oncogene homolog B
生物功能NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. [UniProt]
细胞定位Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome. [UniProt]
预测分子量62 kDa
翻译后修饰Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation. [UniProt]
检测图片 (1)
  • ARG59706 anti-RelB antibody WB image

    Western blot: Raji cell lysate stained with ARG59706 anti-RelB antibody.

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