anti-Renin antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes Renin
  • 反应物种: Hu, Ms, Rat
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: Renin
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 24-160 of Human Renin (NP_000528.1).
  • Brand:
CAT.NO. : ARG41285
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes Renin
反应物种Hu, Ms, Rat
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称Renin
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 24-160 of Human Renin (NP_000528.1).
偶联标记Un-conjugated
別名EC 3.4.23.15; Angiotensinogenase; HNFJ2; Renin
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:200
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照SKOV3
实际分子量45 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 24715 Rat REN

GeneID: 5972 Human REN

Swiss-port # P00797 Human Renin

Swiss-port # P08424 Rat Renin

基因名称REN
全名renin
背景介绍Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
生物功能Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. [UniProt]
细胞定位Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2. [UniProt]
预测分子量45 kDa
检测图片 (1)
  • ARG41285 anti-Renin antibody WB image

    Western blot: 25 ug of SKOV3 cell lysate stained with ARG41285 anti-Renin antibody at 1:1000 dilution.

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