anti-RIPK3 / RIP3 antibody

Key features and details

  • 产品描述: Mouse Monoclonal antibody recognizes RIPK3 / RIP3
  • 反应物种: Hu
  • 应用: WB
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: 2013CT892.86.49
  • 同位型: IgG1, kappa
  • 靶点名称: RIPK3 / RIP3
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG40714
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Product Details
概述
产品描述Mouse Monoclonal antibody recognizes RIPK3 / RIP3
反应物种Hu
应用WB
宿主Mouse
克隆Monoclonal
克隆号2013CT892.86.49
同位型IgG1, kappa
靶点名称RIPK3 / RIP3
抗原物种Human
抗原Recombinant protein of Human RIPK3 / RIP3.
偶联标记Un-conjugated
別名Receptor-interacting serine/threonine-protein kinase 3; Receptor-interacting protein 3; RIP-3; RIP3; RIP-like protein kinase 3; EC 2.7.11.1
应用说明
应用建议
应用推荐稀释比
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量~ 57 kDa
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS and 0.09% (W/V) Sodium azide.
抗菌剂0.09% (W/V) Sodium azide
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 11035 Human RIPK3

Swiss-port # Q9Y572 Human Receptor-interacting serine/threonine-protein kinase 3

基因名称RIPK3
全名receptor-interacting serine-threonine kinase 3
背景介绍The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
生物功能Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. [UniProt]
细胞定位Cytoplasm, cytosol. Cell membrane. Mitochondrion. [UniProt]
产品亮点Related products:
RIPK3 antibodies; RIPK3 Duos / Panels; Anti-Mouse IgG secondary antibodies;
Related news:
RIP1 activation and pathogenesis of NASH
Ripoptosome & Necrosome antibody panels are launched
预测分子量57 kDa
翻译后修饰RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in the necroptotic function of RIPK3. Phosphorylation at Ser-227 is required for binding MLKL.

Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. [UniProt]
检测图片 (1)
  • ARG40714 anti-RIPK3 / RIP3 antibody WB image

    Western blot: 20 µg of K562 whole cell lysate stained with ARG40714 anti-RIPK3 / RIP3 antibody at 1:1000 dilution.

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