anti-RPGR antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG59079
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes RPGR |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | RPGR |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-260 of Human RPGR (NP_001030025.1). |
| 偶联标记 | Un-conjugated |
| 別名 | RP3; CORDX1; X-linked retinitis pigmentosa GTPase regulator; XLRP3; PCDX; orf15; CRD; COD1; RP15 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Mouse heart | ||||||||
| 实际分子量 | 85kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q92834 Human X-linked retinitis pigmentosa GTPase regulator Swiss-port # Q9R0X5 Mouse X-linked retinitis pigmentosa GTPase regulator |
|---|---|
| 基因名称 | RPGR |
| 全名 | retinitis pigmentosa GTPase regulator |
| 背景介绍 | This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined. [provided by RefSeq, Dec 2008] |
| 生物功能 | Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia. [UniProt] |
| 细胞定位 | Cytoplasm, cytoskeleton, flagellum axoneme. Golgi apparatus. Isoform 6: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. [UniProt] |
| 预测分子量 | 113 kDa |
| 翻译后修饰 | Prenylated. [UniProt] |
检测图片 (1)
ARG59079 anti-RPGR antibody WB image
Western blot: 25 µg of Mouse heart lysate stained with ARG59079 anti-RPGR antibody at 1:1000 dilution.
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