anti-RUNX1 + RUNX2 + RUNX3 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG43820
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Size:
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes RUNX1 + RUNX2 + RUNX3 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, WB |
| 特异性 | Human,Mouse |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | RUNX1 + RUNX2 + RUNX3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of human RUNX1/2/3. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Runt-related transcription factor 1/2/3 |
| 別名 | RUNX1; RUNX Family Transcription Factor 1; Runt-Related Transcription Factor 1; AMLCR1; CBFA2; AML1; Polyomavirus Enhancer-Binding Protein 2 Alpha B Subunit; SL3/AKV Core-Binding Factor Alpha B Subunit; SL3-3 Enhancer Factor 1 Alpha B Subunit; Runt Related Transcription Factor 1; Acute Myeloid Leukemia 1 Protein; Oncogene AML-1; PEBP2-Alpha B; PEA2-Alpha B; PEBP2A2; Core-Binding Factor, Runt Domain, Alpha Subunit 2; Core-Binding Factor Subunit Alpha-2; AML1-EVI-1 Fusion Protein; Acute Myeloid Leukemia 1; AML1-ETO Fusion Protein; AML1-ETO Fusion; Aml1 Oncogene; Mutant RUNX1; CBF-Alpha-2; AML1-EVI-1; PEBP2alpha; CBF2alpha; PEBP2aB; EVI-1; RUNX2; RUNX Family Transcription Factor 2; AML3; Runt-Related Transcription Factor 2; CBFA1; Polyomavirus Enhancer-Binding Protein 2 Alpha A Subunit; SL3/AKV Core-Binding Factor Alpha A Subunit; Osteoblast-Specific Transcription Factor 2; SL3-3 Enhancer Factor 1 Alpha A Subunit; Runt Related Transcription Factor 2; Acute Myeloid Leukemia 3 Protein; Oncogene AML-3; PEBP2-Alpha A; PEA2-Alpha A; CBF-Alpha-1; PEBP2aA1; PEBP2A1; OSF-2; CCD1; OSF2; CCD; Core-Binding Factor, Runt Domain, Alpha Subunit 1; Core-Binding Factor Subunit Alpha-1; PEBP2aA; PEA2aA; PEBP2A; CLCD; RUNX3; RUNX Family Transcription Factor 3; AML2; Runt-Related Transcription Factor 3; PEBP2A3; CBFA3; Polyomavirus Enhancer-Binding Protein 2 Alpha C Subunit; SL3/AKV Core-Binding Factor Alpha C Subunit; SL3-3 Enhancer Factor 1 Alpha C Subunit; Runt Related Transcription Factor 3; Core-Binding Factor Subunit Alpha-3; Acute Myeloid Leukemia 2 Protein; Oncogene AML-2; CBF-Alpha-3; Core-Binding Factor, Runt Domain, Alpha Subunit 3; Acute Myeloid Leukemia Gene 2; Transcription Factor AML2; PEBP2 Alpha C; PEBP2-Alpha C; PEA2 Alpha C; PEA2-Alpha C; PEBP2aC |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 49 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | Tris-Glycine, 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q01196 Human Runt-related transcription factor 1 |
|---|---|
| 基因名称 | RUNX1/RUNX2/RUNX3 |
| 全名 | RUNX Family Transcription Factor 1/2/3 |
| 背景介绍 | Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis. [UniProt] |
| 细胞定位 | Cytoplasm, Nucleus. [UniProt] |
| 预测分子量 | 49 kDa |
| 翻译后修饰 | Acetylation, Methylation, Phosphoprotein, Isopeptide bond, Ubl conjugation. [UniProt] |
检测图片 (2)
ARG43820 anti-RUNX1 + RUNX2 + RUNX3 antibody IHC-P image
Immunohistochemistry: mouse colon tissue stained with ARG43820 anti-RUNX1 + RUNX2 + RUNX3 antibody at 1:50 dilution.
ARG43820 anti-RUNX1 + RUNX2 + RUNX3 antibody WB image
Western blot: RAW264.7 cells stained with ARG43820 anti-RUNX1 + RUNX2 + RUNX3 antibody at 1:500 dilution.
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