anti-S6 Ribosomal Protein antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG57446
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody recognizes S6 Ribosomal Protein |
|---|---|
| 反应物种 | Hu, Ms, Rat, Mk |
| 应用 | ICC/IF, IP, WB |
| 特异性 | This antibody detects endogenous levels of total S6 Ribosomal Protein independent of phosphorylation. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | S6 Ribosomal Protein |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human S6 Ribosomal Protein. |
| 偶联标记 | Un-conjugated |
| 別名 | Phosphoprotein NP33; 40S ribosomal protein S6; S6 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 0.03% Proclin300 and 50% Glycerol. |
| 抗菌剂 | 0.03% Proclin300 |
| 稳定剂 | 50% Glycerol |
| 浓度 | 2.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | RPS6 |
| 全名 | ribosomal protein S6 |
| 背景介绍 | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] |
| 生物功能 | May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. [UniProt] |
| 细胞定位 | Cytoplasm. |
| 预测分子量 | 29 kDa |
| 翻译后修饰 | Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex. |
检测图片 (2)
ARG57446 anti-S6 Ribosomal Protein antibody ICC/IF image
Immunofluorescence: HeLa cells fixed with 4% Paraformaldehyde and stained with ARG57446 anti-S6 Ribosomal Protein antibody at 1:200 dilution.
ARG57446 anti-S6 Ribosomal Protein antibody WB image
Western blot: Raji cell lysate stained with ARG57446 anti-S6 Ribosomal Protein antibody at 1:2000 dilution.
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