anti-SARS-CoV / SARS-CoV-2 Spike protein (RBD) antibody [CR3022]
![anti-SARS-CoV / SARS-CoV-2 Spike protein (RBD) antibody [CR3022]](/upload/image/products/ARG66739_ELISA_1_210_205.jpg)
![anti-SARS-CoV / SARS-CoV-2 Spike protein (RBD) antibody [CR3022]](/upload/image/products/ARG66739_IF_210813.jpg)
![anti-SARS-CoV / SARS-CoV-2 Spike protein (RBD) antibody [CR3022]](/upload/image/products/ARG66739_ELISA_1.jpg)
Key features and details
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CAT.NO. : ARG66739
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Product Details
概述
| 产品描述 | Recombinant Human Monoclonal antibody [CR3022] recognizes SARS-CoV / SARS-CoV-2 Spike protein (RBD) |
|---|---|
| 反应物种 | Virus |
| 应用 | ELISA, ICC/IF, Neut |
| 特异性 | This antibody binds the amino acids 318-510 in the S1 domain (RBD, Receptor Binding Domain) of the SARS-CoV Spike protein as well as SARS-CoV-2 (COVID-19) Spike protein. The antibody also binds to P462L-substituted S318–510 fragments of the SARS spike protein. The binding epitope is only accessible in the "open" conformation of the spike protein (Joyce et al. 2020) |
| 宿主 | Human |
| 克隆 | Monoclonal |
| 克隆号 | CR3022 |
| 同位型 | IgG1 |
| 靶点名称 | SARS-CoV / SARS-CoV-2 Spike protein (RBD) |
| 抗原物种 | Virus |
| 偶联标记 | Un-conjugated |
应用说明
| 应用建议 |
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| 应用说明 | Neutralizing: Clone CR3022 is the first anti-SARS-CoV neutralizing antibody to cross-react with SARS-CoV-2. Structural modeling has confirmed that CR3022 targets a conserved epitope between SARS-CoV and SARS-CoV2 in the RBD domain (PMID: 32245784, 32065055). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from antibody expressing HEK293 cell culture medium. |
| 纯度 | > 98% (SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
检测图片 (2)
ARG66739 anti-SARS-CoV / SARS-CoV-2 Spike protein (RBD) antibody [CR3022] ICC/IF image
Immunofluorescence: 293T cells were transfected with Mock or SARS-CoV-2 Spike expression plasmid. Cells were stained with ARG66739 anti-SARS-CoV / SARS-CoV-2 Spike protein (RBD) antibody [CR3022] (green). DAPI (blue) for nuclear staining.
ARG66739 anti-SARS-CoV / SARS-CoV-2 Spike protein (RBD) antibody [CR3022] ELISA image
ELISA: Titration of ARG66739 anti-SARS-CoV / SARS-CoV-2 Spike protein (RBD) antibody [CR3022].
RBD = Receptor binding domain
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