anti-SF1 antibody [SQab30309]

Key features and details

  • 产品描述: Recombinantrabbit Monoclonal antibody [SQab30309] recognizes SF1
  • 反应物种: Hu
  • 应用: IHC-P
  • 宿主: Rabbit
  • 克隆: Monoclonal
  • 克隆号: SQab30309
  • 同位型: IgG
  • 靶点名称: SF1
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG67046
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Product Details
概述
产品描述Recombinantrabbit Monoclonal antibody [SQab30309] recognizes SF1
反应物种Hu
应用IHC-P
宿主Rabbit
克隆Monoclonal
克隆号SQab30309
同位型IgG
靶点名称SF1
抗原物种Human
抗原Recombinant protein of Human SF1.
偶联标记Un-conjugated
Protein Full nameSteroidogenic factor 1
別名SF1, Splicing Factor 1, ZFM1, Zinc Finger Protein 162, ZCCHC25, ZNF162, Mammalian Branch Point-Binding Protein, Zinc Finger Gene In MEN1 Locus, Transcription Factor ZFM1, MBBP, BBP, D11S636
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:100
应用说明The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Adrenocortical adenoma
属性
形式Liquid
纯化Purification with Protein A.
缓冲液PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA.
抗菌剂0.01% Sodium azide
稳定剂40% Glycerol and 0.05%BSA
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 7536 Human SF1

Swiss-port # Q15637 Human Splicing factor 1

基因名称SF1
全名Splicing Factor 1
背景介绍This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
生物功能Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. [UniProt]
细胞定位Nucleus; Spliceosome
预测分子量68 kDa
翻译后修饰Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463. [UniProt]
检测图片 (1)
  • ARG67046 anti-SF1 antibody [SQab30309] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded adrenocortical adenoma stained with adrenocortical adenoma ARG67046 anti-SF1 antibody [SQab30309].

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