anti-SHP1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG64175
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Product Details
概述
| 产品描述 | Goat Polyclonal antibody recognizes SHP1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 预测物种 | Dog |
| 应用 | IHC-P, WB |
| 特异性 | This antibody is expected to recognise both reported isoforms (NP_536858.1and NP_002822.2). _x000D_Please note this antibody was designed using the mouse sequence, which differs by 1 amino acid from the human sequence. |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SHP1 |
| 抗原物种 | Human |
| 抗原 | C-KASRTSSKHKEE |
| 偶联标记 | Un-conjugated |
| 別名 | HCP; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase SHP-1; SH-PTP1; PTP-1C; HPTP1C; HCPH; Tyrosine-protein phosphatase non-receptor type 6; SHP-1; EC 3.1.3.48; SHP1; SHP-1L; Protein-tyrosine phosphatase 1C |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 背景介绍 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Signaling Transduction antibody |
| 预测分子量 | 68 kDa |
| 翻译后修饰 | Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity. |
检测图片 (3)
ARG64175 anti-SHP1 antibody WB image
Western blot: Human Liver lysate (35 µg protein in RIPA buffer) stained with ARG64175 anti-SHP1 antibody at 0.1 µg/ml dilution.
ARG64175 anti-SHP1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human thyroid tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG64175 anti-SHP1 antibody at 5 µg/ml dilution followed by AP-staining.
ARG64175 anti-SHP1 antibody WB image
Western blot: 35 µg of Mouse thymus (A) and Rat thymus (B) lysates (in RIPA buffer) stained with ARG64175 anti-SHP1 antibody at 0.01 µg/ml (A) and 0.1 µg/ml (B) dilutions and incubated at RT for 1 hour.
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