anti-SHP2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG55762
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SHP2 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Chk |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SHP2 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 526-551 of Human SHP2. |
| 偶联标记 | Un-conjugated |
| 別名 | BPTP3; SHP-2; Protein-tyrosine phosphatase 2C; METCDS; PTP2C; Tyrosine-protein phosphatase non-receptor type 11; PTP-1D; CFC; PTP-2C; JMML; Shp2; Protein-tyrosine phosphatase 1D; NS1; EC 3.1.3.48; SH-PTP2; SH-PTP3; SHP2 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q06124 Human Tyrosine-protein phosphatase non-receptor type 11 |
|---|---|
| 基因名称 | PTPN11 |
| 全名 | protein tyrosine phosphatase, non-receptor type 11 |
| 背景介绍 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
| 生物功能 | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. [UniProt] |
| 细胞定位 | Cytoplasm. |
| 产品亮点 | Related products: SHP2 antibodies; Anti-Rabbit IgG secondary antibodies; Related news: Tools for studying H. pylori diseases |
| 预测分子量 | 68 kDa |
| 翻译后修饰 | Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB. |
检测图片 (3)
ARG55762 anti-SHP2 antibody WB image
Western blot: 30 µg of HCT116 and A549 cell lysates stained with ARG55762 anti-SHP2 antibody at 1:1000 dilution.
ARG55762 anti-SHP2 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human hepatocarcinoma stained with ARG55762 anti-SHP2 antibody.
ARG55762 anti-SHP2 antibody FACS image
Flow Cytometry: 293 cells stained with ARG55762 anti-SHP2 antibody (bottom histogram) or without primary antibody control (top histogram), followed by incubation with FITC labelled secondary antibody.
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