anti-Siglec 10 antibody [5G6] (APC)

CAT.NO. : ARG44609

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Size:

100 tests

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Product Details

概述

产品描述	APC-conjugated Mouse Monoclonal antibody recognizes Siglec 10
反应物种	Hu
应用	FACS
宿主	Mouse
克隆	Monoclonal
克隆号	5G6
同位型	IgG1
靶点名称	Siglec 10
抗原物种	Human
抗原	SIGLEC10 extracellular domain fused with human IgG1 Fc fragment
偶联标记	APC
別名	SIGLEC10; Sialic Acid Binding Ig Like Lectin 10; SLG2; SIGLEC-10; PRO940; Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7; Sialic Acid-Binding Ig-Like Lectin 10; Siglec-Like Protein 2; Siglec-Like Gene 2; MGC126774; Sialic Acid Binding Ig-Like Lectin 10; Siglec-10

应用说明

应用建议

应用	推荐稀释比
FACS	10 µl / 100 µl or 10^6 cells

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purified antibody is conjugated with activated allophycocyanin (APC), and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
缓冲液	PBS (pH 7.4) and 15 mM Sodium azide
抗菌剂	15 mM Sodium azide
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 89790 Human SIGLEC10 Swiss-port # Q96LC7 Human Sialic acid-binding Ig-like lectin 10
基因名称	SIGLEC10
全名	sialic acid binding Ig-like lectin 10
背景介绍	SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
生物功能	During initiation of adaptive immune responses by CD8-alpha+ dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification. [UniProt]
细胞定位	Cell membrane, Membrane, Secreted. [UniProt]
预测分子量	77 kDa
翻译后修饰	Disulfide bond, Glycoprotein, Phosphoprotein. [UniProt]

检测图片 (1)

ARG44609 anti-Siglec 10 antibody [5G6] (APC) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG44609 anti-Siglec 10 antibody [5G6] (APC) at 10 μl/ 100 μl dilution.

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