anti-Siglec 10 antibody [5G6]
![anti-Siglec 10 antibody [5G6]](/upload/image/products/ARG23301_FACS_1_210_205.jpg)
![anti-Siglec 10 antibody [5G6]](/upload/image/products/ARG23301_FACS_1.jpg)
Key features and details
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- 克隆:
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- 靶点名称:
- 抗原物种:
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CAT.NO. : ARG23301
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [5G6] recognizes Siglec 10 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 5G6 |
| 同位型 | IgG1 |
| 靶点名称 | Siglec 10 |
| 抗原物种 | Human |
| 抗原 | Recombinant Human Siglec-10, fused with the Fc region of Human IgG. |
| 偶联标记 | Un-conjugated |
| 別名 | SIGLEC10; Sialic Acid Binding Ig Like Lectin 10; SLG2; SIGLEC-10; PRO940; Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7; Sialic Acid-Binding Ig-Like Lectin 10; Siglec-Like Protein 2; Siglec-Like Gene 2; MGC126774; Sialic Acid Binding Ig-Like Lectin 10; Siglec-10 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS and 0.09% Sodium azide. |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q96LC7 Human Sialic acid-binding Ig-like lectin 10 |
|---|---|
| 基因名称 | SIGLEC10 |
| 全名 | sialic acid binding Ig-like lectin 10 |
| 背景介绍 | SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002] |
| 生物功能 | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. [UniProt] |
| 细胞定位 | Cell membrane, Membrane, Secreted. [UniProt] |
| 预测分子量 | 77 kDa |
| 翻译后修饰 | Phosphorylation of Tyr-667 is involved in binding to PTPN6. [UniProt] |
检测图片 (1)
ARG23301 anti-Siglec 10 antibody [5G6] FACS image
Flow Cytometry: Siglec-10 tranfected CHO cells stained with ARG23301 anti-Siglec 10 antibody [5G6] followed by Rabbit F(ab')2 anti Mouse IgG (FITC).
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