anti-SIK3 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG40314
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Product Details
概述
| 产品描述 | Chicken Polyclonal antibody recognizes SIK3 |
|---|---|
| 反应物种 | Hu, Rat |
| 预测物种 | Ms |
| 应用 | ICC/IF, WB |
| 特异性 | At least three isoforms of SIK3 are known to exist. This antibody will detect two isoforms. This SIK3 antibody is predicted to not cross-react with SIK1 and SIK2. |
| 宿主 | Chicken |
| 克隆 | Polyclonal |
| 同位型 | IgY |
| 靶点名称 | SIK3 |
| 抗原物种 | Human |
| 抗原 | An 18 amino acid synthetic peptide within aa. 1190 - 1240 of Human SIK3. |
| 偶联标记 | Un-conjugated |
| 別名 | SIK-3; L19; QSK; Serine/threonine-protein kinase SIK3; Salt-inducible kinase 3; Serine/threonine-protein kinase QSK; EC 2.7.11.1 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Rat brain |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9Y2K2 Human Serine/threonine-protein kinase SIK3 |
|---|---|
| 基因名称 | SIK3 |
| 全名 | SIK family kinase 3 |
| 生物功能 | Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling. [UniProt] |
| 细胞定位 | Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ. [UniProt] |
| 预测分子量 | Isoform 1: 145 kDa Isoform 2: 70 kDa |
| 翻译后修饰 | Phosphorylated at Thr-163 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. [UniProt] |
检测图片 (2)
ARG40314 anti-SIK3 antibody ICC/IF image
Immunofluorescence: Rat brain cells stained with ARG40314 anti-SIK3 antibody at 20 µg/ml dilution.
ARG40314 anti-SIK3 antibody WB image
Western blot: Rat brain lysate stained with ARG40314 anti-SIK3 antibody at 1 µg/ml dilution in the absence (left) and the presence (right) of blocking peptide.
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