anti-SIX3 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes SIX3
  • 反应物种: Ms, Rat
  • 预测物种: Hu
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: SIX3
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG59101
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes SIX3
反应物种Ms, Rat
预测物种Hu
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称SIX3
抗原物种Human
抗原Synthetic peptide corresponding to aa. 1-32 of Human SIX3. (MVFRSPLDLYSSHFLLPNFADSHHRSILLASS).
偶联标记Un-conjugated
別名HPE2; Homeobox protein SIX3; Sine oculis homeobox homolog 3
应用说明
应用建议
应用推荐稀释比
WB0.1 - 0.5 µg/ml
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA.
抗菌剂0.05% Sodium azide
稳定剂5% BSA
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 20473 Mouse SIX3

Swiss-port # Q62233 Mouse Homeobox protein SIX3

基因名称SIX3
全名SIX homeobox 3
背景介绍This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]
生物功能Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is AES and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway. [UniProt]
细胞定位Nucleus. [UniProt]
预测分子量35 kDa
检测图片 (1)
  • ARG59101 anti-SIX3 antibody WB image

    Western blot: 50 µg of samples under reducing conditions. Rat brain and Mouse brain lysates stained with ARG59101 anti-SIX3 antibody at 0.5 µg/ml, overnight at 4°C.

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