anti-Skeletal Troponin T antibody [T1/61]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [T1/61] recognizes Skeletal Troponin TThis antibody recognizes the canonical isoform 1, binding to othe potential isoforms has not been evaluated (UniProt : P12620).
  • 反应物种: Hu, Chk
  • 不反应物种: Rb
  • 应用: ELISA, ICC/IF, IHC-Fr, IHC-P, WB
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: T1/61
  • 同位型: IgG1
  • 靶点名称: Skeletal Troponin T
  • Brand:
CAT.NO. : ARG22574
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Product Details
概述
产品描述Mouse Monoclonal antibody [T1/61] recognizes Skeletal Troponin T
This antibody recognizes the canonical isoform 1, binding to othe potential isoforms has not been evaluated (UniProt : P12620).
反应物种Hu, Chk
不反应物种Rb
应用ELISA, ICC/IF, IHC-Fr, IHC-P, WB
宿主Mouse
克隆Monoclonal
克隆号T1/61
同位型IgG1
靶点名称Skeletal Troponin T
抗原物种Chicken
抗原Troponin T, purified from chicken breast muscle
偶联标记Un-conjugated
別名fTnT; Fast skeletal muscle troponin T; Troponin T, fast skeletal muscle; TnTf; TNTF; Beta-TnTF
应用说明
应用建议
应用推荐稀释比
ELISAAssay-dependent
ICC/IFAssay-dependent
IHC-FrAssay-dependent
IHC-PAssay-dependent
WBAssay-dependent
应用说明IHC: This product does not require protein digestion pre-treatment of paraffin sections.This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS and 0.09% Sodium azide
抗菌剂0.09% Sodium azide
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 7140 Human TNNT3

Swiss-port # P45378 Human Troponin T, fast skeletal muscle

基因名称TNNT3
全名troponin T3, fast skeletal type
背景介绍The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
生物功能Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. [UniProt]
预测分子量32 kDa
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