anti-SLCO1B1 / OATP1B1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG43402
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SLCO1B1 / OATP1B1 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SLCO1B1 / OATP1B1 |
| 抗原物种 | Human |
| 抗原 | A 14-amino acid synthetic peptide within aa. 641-691 of Human SLCO1B1 / OATP1B1. |
| 偶联标记 | Un-conjugated |
| 別名 | OATP-C; LST1; OATPC; SLC21A6; HBLRR; LST-1; Sodium-independent organic anion-transporting polypeptide 2; OATP-2; OATP2; Solute carrier organic anion transporter family member 1B1; Solute carrier family 21 member 6; Liver-specific organic anion transporter 1; OATP1B1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human liver | ||||||
| 实际分子量 | ~ 80 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9Y6L6 Human Solute carrier organic anion transporter family member 1B1 |
|---|---|
| 基因名称 | SLCO1B1 |
| 全名 | solute carrier organic anion transporter family, member 1B1 |
| 背景介绍 | This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009] |
| 生物功能 | Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. [UniProt] |
| 细胞定位 | Basolateral cell membrane; Multi-pass membrane protein. Note=Detected in basolateral membranes of hepatocytes. [UniProt] |
| 预测分子量 | 76 kDa |
检测图片 (2)
ARG43402 anti-SLCO1B1 / OATP1B1 antibody ICC image
Immunocytochemistry: HepG2 cells stained with ARG43402 anti-SLCO1B1 / OATP1B1 antibody at 2.5 µg/ml dilution.
ARG43402 anti-SLCO1B1 / OATP1B1 antibody WB image
Western blot: Human liver lysate stained with ARG43402 anti-SLCO1B1 / OATP1B1 antibody at 1 µg/ml dilution.
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