anti-SLCO1B3 / OATP1B3 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG43401
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SLCO1B3 / OATP1B3 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SLCO1B3 / OATP1B3 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide between aa. 639-668 of Human SLCO1B3 / OATP1B3. |
| 偶联标记 | Un-conjugated |
| 別名 | Organic anion-transporting polypeptide 8; LST3; Liver-specific organic anion transporter 2; OATP1B3; LST-3TM13; HBLRR; LST-2; SLC21A8; Solute carrier family 21 member 8; Organic anion transporter 8; OATP-8; Solute carrier organic anion transporter family member 1B3; OATP8 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HeLa and NCI-H460 | ||||
| 实际分子量 | 85, 110-120 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9NPD5 Human Solute carrier organic anion transporter family member 1B3 |
|---|---|
| 基因名称 | SLCO1B3 |
| 全名 | solute carrier organic anion transporter family, member 1B3 |
| 背景介绍 | This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017] |
| 生物功能 | Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver. [UniProt] |
| 细胞定位 | Basolateral cell membrane; Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 77 kDa |
| 翻译后修饰 | N-glycosylated. [UniProt] |
检测图片 (2)
ARG43401 anti-SLCO1B3 / OATP1B3 antibody WB image
Western blot: 20 µg of HeLa whole cell lysate stained with ARG43401 anti-SLCO1B3 / OATP1B3 antibody at 1:2000 dilution.
ARG43401 anti-SLCO1B3 / OATP1B3 antibody WB image
Western blot: 20 µg of NCI-H460 whole cell lysate stained with ARG43401 anti-SLCO1B3 / OATP1B3 antibody at 1:2000 dilution.
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