anti-Slug antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes Slug
  • 反应物种: Hu, Ms, Rat
  • 应用: WB
  • 特异性: The antibody detects endogenous Slug protein.
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: Slug
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG66293
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes Slug
反应物种Hu, Ms, Rat
应用WB
特异性The antibody detects endogenous Slug protein.
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称Slug
抗原物种Human
抗原Recombinant Protein of Human Slug.
偶联标记Un-conjugated
別名Protein snail homolog 2; SNAIL2; WS2D; Neural crest transcription factor Slug; Zinc finger protein SNAI2; SLUG; SLUGH1
应用说明
应用建议
应用推荐稀释比
WB1:500 - 1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量~ 30 kDa
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 20583 Mouse SNAI2

GeneID: 25554 Rat SNAI2

GeneID: 6591 Human SNAI2

基因名称SNAI2
全名snail family zinc finger 2
背景介绍This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
生物功能Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. [UniProt]
预测分子量30 kDa
翻译后修饰GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation. [UniProt]
检测图片 (1)
  • ARG66293 anti-Slug antibody WB image

    Western blot: MCF7, Mouse heart, Rat heart and Rat brain lysates stained with ARG66293 anti-Slug antibody.

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