anti-SORL1 / SorLA antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes SORL1 / SorLA
  • 反应物种: Hu
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: SORL1 / SorLA
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 2065-2214 of Human SORL1 (NP_003096.1).
  • Brand:
CAT.NO. : ARG41056
US$ Please choose
US$ Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整,请以品牌方官网实时更新的价格为准,以确保准确性。
Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes SORL1 / SorLA
反应物种Hu
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称SORL1 / SorLA
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 2065-2214 of Human SORL1 (NP_003096.1).
偶联标记Un-conjugated
別名SorLA-1; SorLA; LRP9; LR11; C11orf32; SORLA; gp250; Sorting protein-related receptor containing LDLR class A repeats; LDLR relative with 11 ligand-binding repeats; Sortilin-related receptor; Low-density lipoprotein receptor relative with 11 ligand-binding repeats
应用说明
应用建议
应用推荐稀释比
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照HepG2
实际分子量290 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 6653 Human SORL1

Swiss-port # Q92673 Human Sortilin-related receptor

基因名称SORL1
全名sortilin-related receptor, L(DLR class) A repeats containing
背景介绍This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.[provided by RefSeq, Sep 2010]
生物功能Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization. [UniProt]
细胞定位Membrane; Single-pass type I membrane protein. Golgi apparatus. Endosome. Secreted. [UniProt]
预测分子量248 kDa
翻译后修饰The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases. [UniProt]
检测图片 (1)
  • ARG41056 anti-SORL1 / SorLA antibody WB image

    Western blot: 25 µg of HepG2 cell lysate stained with ARG41056 anti-SORL1 / SorLA antibody at 1:3000 dilution.

New Products
Get in touch with AREX
Name:*
Tel/Phone:*
Company:*
Email:*
Inquiry:
Captcha*
Submitting your email information means that you are willing to receive email information from AREX regarding technology, applications, products, and events. By clicking on the 'unsubscribe' button in the email or by contacting info@arexbio.com You can unsubscribe at any time by sending an email. Regarding your data usage information, please refer to our privacy policy.
© AREX 2024. All Rights Reserved. | 浙ICP备2024113709号-3 Sitemap