anti-SSB antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG57448
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody recognizes SSB |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 特异性 | This antibody detects endogenous levels of SSB and does not cross-react with related proteins. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | SSB |
| 抗原物种 | Human |
| 抗原 | Purified recombinant Human SSB protein fragments expressed in E. coli. |
| 偶联标记 | Un-conjugated |
| 別名 | LARP3; Sjoegren syndrome type B antigen; La; La ribonucleoprotein; Lupus La protein; La autoantigen; La/SSB; SS-B |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 0.03% Proclin300 and 50% Glycerol. |
| 抗菌剂 | 0.03% Proclin300 |
| 稳定剂 | 50% Glycerol |
| 浓度 | 2.6 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SSB |
| 全名 | Sjogren syndrome antigen B (autoantigen La) |
| 背景介绍 | The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014] |
| 生物功能 | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. [UniProt] |
| 细胞定位 | Nucleus. |
| 预测分子量 | 47 kDa |
| 翻译后修饰 | Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein. The N-terminus is blocked. |
检测图片 (1)
ARG57448 anti-SSB antibody WB image
Western blot: A549 cell lysate stained with ARG57448 anti-SSB antibody at 1:1000 dilution.
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