anti-STAT2 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes STAT2
  • 反应物种: Hu, Ms, Rat
  • 应用: ICC/IF, IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: STAT2
  • 抗原物种: Human
  • 抗原: Synthetic peptide derived from Human Stat2.
  • Brand:
CAT.NO. : ARG57599
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes STAT2
反应物种Hu, Ms, Rat
应用ICC/IF, IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称STAT2
抗原物种Human
抗原Synthetic peptide derived from Human Stat2.
偶联标记Un-conjugated
別名P113; Signal transducer and activator of transcription 2; STAT113; p113; ISGF-3
应用说明
应用建议
应用推荐稀释比
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
WB1:1000 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 20847 Mouse STAT2

GeneID: 288774 Rat STAT2

GeneID: 6773 Human STAT2

Swiss-port # P52630 Human Signal transducer and activator of transcription 2

基因名称STAT2
全名signal transducer and activator of transcription 2, 113kDa
背景介绍The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
生物功能Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. [UniProt]
细胞定位Late endosome membrane > Peripheral membrane protein
产品亮点Related products:
STAT2 antibodies; Anti-Rabbit IgG secondary antibodies;
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预测分子量98 kDa
翻译后修饰Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response. [UniProt]
检测图片 (3)
  • ARG57599 anti-STAT2 antibody ICC/IF image

    Immunofluorescence: A431 cells stained with ARG57599 anti-STAT2 antibody.

  • ARG57599 anti-STAT2 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human lung cancer tissue stained with ARG57599 anti-STAT2 antibody.

  • ARG57599 anti-STAT2 antibody WB image

    Western blot: K562 cell lysate stained with ARG57599 anti-STAT2 antibody.

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