anti-STAT4 phospho (Tyr693) antibody
Key features and details
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- 靶点名称:
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- 抗原:
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Brand:
CAT.NO. : ARG41885
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes STAT4 phospho (Tyr693) |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | STAT4 |
| 抗原物种 | Human |
| 抗原 | Phosphospecific peptide around Tyr693 of Human STAT4. |
| 偶联标记 | Un-conjugated |
| 別名 | SLEB11; Signal transducer and activator of transcription 4 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HepG2 + IL4 | ||||||
| 实际分子量 | ~ 86 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P42228 Mouse Signal transducer and activator of transcription 4 Swiss-port # Q14765 Human Signal transducer and activator of transcription 4 |
|---|---|
| 基因名称 | STAT4 |
| 全名 | signal transducer and activator of transcription 4 |
| 背景介绍 | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] |
| 生物功能 | Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. [UniProt] |
| 预测分子量 | 86 kDa |
| 翻译后修饰 | Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). [UniProt] |
检测图片 (2)
ARG41885 anti-STAT4 phospho (Tyr693) antibody WB image
Western blot: HepG2 cells were treated by IL4 (100 ng/ml) at 37°C for 30 minutes after serum-starvation overnight. 25 µg of cell lysate stained with ARG41885 anti-STAT4 phospho (Tyr693) antibody.
ARG41885 anti-STAT4 phospho (Tyr693) antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human breast carcinoma tissue stained with ARG41885 anti-STAT4 phospho (Tyr693) antibody.
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